Mutations in Epidermal Growth Factor Receptor Gene in Esophageal
Abstract
Activating mutations in Epidermal Growth Factor Receptor (EGFR) are common in lung
adenocarcinoma of never smokers but are rare in other types of cancer. Here we have
analysed mutations in exons 19 to 21 of EGFR and in exons 19 and 20 of the EGFR
homolog HER2 in 54 cases of Esophageal Squamous Cell Carcinomas (ESCC) from
patients recruited in Kashmir, India, a region of high incidence for this cancer. We report
the detection of 3 mutations (6%) in the ATP-binding regulatory loops of the tyrosine
kinase domain of EGFR (deletion 746-750, P753L, G719D). No mutation was found in
HER2. This is the first report of activating EGFR mutations in ESCC, of the same type as
those detected in lung adenocarcinoma of never-smokers. This suggests that a small
proportion of ESCC patients in this high incidence area may benefit from treatment with
EGFR tyrosine kinase inhibitors.
Key words : EGFR, Mutations, Esophageal Cancer, Kashmir
adenocarcinoma of never smokers but are rare in other types of cancer. Here we have
analysed mutations in exons 19 to 21 of EGFR and in exons 19 and 20 of the EGFR
homolog HER2 in 54 cases of Esophageal Squamous Cell Carcinomas (ESCC) from
patients recruited in Kashmir, India, a region of high incidence for this cancer. We report
the detection of 3 mutations (6%) in the ATP-binding regulatory loops of the tyrosine
kinase domain of EGFR (deletion 746-750, P753L, G719D). No mutation was found in
HER2. This is the first report of activating EGFR mutations in ESCC, of the same type as
those detected in lung adenocarcinoma of never-smokers. This suggests that a small
proportion of ESCC patients in this high incidence area may benefit from treatment with
EGFR tyrosine kinase inhibitors.
Key words : EGFR, Mutations, Esophageal Cancer, Kashmir
Mir, M. M., Dar, N. A., Salam, I., & Shah, Z. A. (2008). Mutations in Epidermal Growth Factor Receptor Gene in Esophageal. International Journal of Health Sciences, 2(2). Retrieved from https://ijhs.qu.edu.sa/index.php/journal/article/view/47
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