Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report

Abdulaziz AlSalloom
dr.abdulaziz.s@hotmail.com (Primary Contact)
Salman T Al Malki
Department of Pathology, Riyadh Armed Forces Hospital
Hadeel Al Mana
Department of Pathology, King Faisal Specialist Hospital and Research Centre
Martin Burdelski
Department of Organ Transplant, King Faisal Specialist Hospital and Research Centre
PDF

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease that usually affects children and young adults. Sclerosing cholangitis (SC) can occur in 10-15% of patients with disseminated form of the disease. Central diabetes insipidus (CDI) is a rare disorder that may be caused by a variety of diseases mainly LCH and germinoma especially in children. In this case report, a- 4-year-old girl who is a known case of CDI and a single bone lesion in the left humerus, presented with jaundice, abdominal distention and itching. The diagnosis of SC was made by histopathology on liver biopsy. In this case, we found a link between CDI and SC through LCH, the diagnosis of which was made by histopathology of the explanted liver. The combination of CDI, liver involvement with SC and a single bone lesion is remarkable, since the histological diagnosis of LCH was made outside the biliary tract in the liver parenchyma.
Table of Contents
AlSalloom, A., Al Malki, S. T., Al Mana, H., & Burdelski, M. (2013). Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report. International Journal of Health Sciences, 7(2). Retrieved from https://ijhs.qu.edu.sa/index.php/journal/article/view/428

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Copyright and license info is not available
Author biographies is not available.