Susceptibility profile of methicillin-resistant Staphylococcus aureus to linezolid in clinical isolates
Abstract
Objective: To determine the resistance and sensitivity pattern of Methicillin-Resistant Staphylococcus aureus (MRSA) isolates to Linezolid along with its prevalence in a tertiary care hospital of Karachi, Pakistan
Methods and Materials: A Cross sectional study was carried out. This study lasted for about 1 year. Prevalence and sensitivity of linezolid, Vancomycin and Oxacillin was tested against isolates of MRSA.
Results: Out of total 369 specimens 165 were found to be MRSA making the prevalence in our study 44.7% .All of the isolates which were tested positive for MRSA were susceptible to linezolid and no resistance was noted when compared with previous studies performed in Europe and USA.
Conclusion: Stringent implementation of infection control measures along with screening for resistance in patients on prolonged Linezolid therapy or who previously went under linezolid therapy should be performed, coupled with judicious usage of the aforementioned antibiotic should be undertaken, as sufficient data is not available at this point for the clinical spectrum of Linezolid resistant Staphylococcus aureus (LRSA), antimicrobial resistance.
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